医药
Targeting Cellular Senescence: A New Frontier in Combating Cancer and Age-Related Diseases
In the realm of cellular biology, senescence has emerged as a pivotal process influencing both the progression of cancer and the onset of age-related diseases. Defined as a state where cells cease to divide but remain metabolically active, senescence acts as a double-edged sword. Key life sciences companies are pinning pipeline hopes in cracking this.
Navigating the New Frontier: The First Abridged Complaint under the 2024 ABPI Code
In the ever-evolving landscape of pharmaceutical marketing, the industry faces a delicate balance between informing the public and adhering to strict regulations. This challenge was thrust into the spotlight with the recent case of CSL Seqirus and the alleged promotion of their prescription-only Flucelvax Influenza vaccine on the social media platform LinkedIn.
稳定性 Oracle:设计稳定蛋白质的强大工具
在飞速发展的生物技术领域,能否设计出稳定性更强的蛋白质是一项严峻的挑战。能够准确预测氨基酸突变将如何影响蛋白质热力学稳定性的计算方法将彻底改变蛋白质工程过程。 Stability Oracle 是一种新的深度学习框架,在预测热力学稳定蛋白质突变方面优于最先进的方法。
美国精神分裂症治疗的新纪元:FDA 批准 COBENFY
美国食品和药物管理局 (FDA) 批准使用 COBENFY™(赛诺梅林和氯化曲司匹林),这是神经精神医学领域的一项重大进展,标志着几十年来首次采用新的药物方法治疗精神分裂症。
健康
Unveiling Injustice: The Imperative of Addressing Racism in Global Child Health
The recently launched Lancet Commission on Racism and Child Health has embarked on a pioneering journey to unravel the profound impact of racism, xenophobia, and discrimination on child health worldwide. This editorial delves into the multifaceted dimensions of this issue, exploring the pathways through which racism affects health outcomes and highlighting the urgent need for systemic change.
反思预防自杀:以公共卫生方法解决全球问题
自杀是一个重大的公共健康危机,每年在全球夺去 70 多万人的生命。然而,尽管自杀造成的损失令人震惊,但它却是一个可以预防的悲剧。一个新的框架正在形成,它可以改变我们处理这一复杂问题的方式--将重点从个人层面的风险因素转移到影响不同人群自杀风险的更广泛的社会决定因素上
智取真菌入侵者病原体如何劫持我们的免疫防御系统
真菌对人类健康的主要威胁常常被忽视,而细菌和病毒感染所造成的巨大影响则使其黯然失色。然而,这些真核微生物却构成了日益严重的威胁,每年造成全球数百万人死亡。而它们的成功在很大程度上是因为它们有能力操纵我们赖以保持健康的免疫防御系统。
科学、技术
Targeting Cellular Senescence: A New Frontier in Combating Cancer and Age-Related Diseases
In the realm of cellular biology, senescence has emerged as a pivotal process influencing both the progression of cancer and the onset of age-related diseases. Defined as a state where cells cease to divide but remain metabolically active, senescence acts as a double-edged sword. Key life sciences companies are pinning pipeline hopes in cracking this.
Hydroclimate Volatility: Navigating Extremes on a Warming Earth
In the face of a rapidly changing climate, the concept of hydroclimate volatility has emerged as a critical area of study, highlighting the dramatic and often sudden fluctuations between extremely dry and wet conditions. This phenomenon poses significant challenges to both natural ecosystems and human societies
Dear World Leaders, A Clarion Call to Action: Addressing the Peril of Antarctic Sea Ice Loss
We write to you today with a profound sense of alarm and a pressing need for urgent action. The events unfolding in the Antarctic are a stark harbinger of the dangers posed by climate change, and they demand an immediate and concerted global response.
征服连接组绘制大脑的秘密
Seung 和 Murthy 利用电子显微镜拍摄的苍蝇大脑切片图像,开发 FlyWire 地图已有四年多时间。在人工智能(AI)工具的帮助下,研究人员及其数百名全球同事将数据拼接在一起,形成了完整的大脑地图。这是一项巨大的成就,已经在该领域掀起了一场革命。
稳定性 Oracle:设计稳定蛋白质的强大工具
在飞速发展的生物技术领域,能否设计出稳定性更强的蛋白质是一项严峻的挑战。能够准确预测氨基酸突变将如何影响蛋白质热力学稳定性的计算方法将彻底改变蛋白质工程过程。 Stability Oracle 是一种新的深度学习框架,在预测热力学稳定蛋白质突变方面优于最先进的方法。
埋藏的宝藏:火星粘土如何揭开地球神秘的过去
早期的火星大气层曾经充满二氧化碳,但随着时间的推移,这种浓厚的大气层急剧变薄。这些碳都去哪儿了呢?答案可能就在覆盖在火星表面的岩石和矿物中
将木质素转化为喷气燃料:可持续的航空突破
随着全球航空业努力减少对环境的影响,开发可替代传统石油喷气燃料的可持续航空燃料(SAF)的竞赛也在进行。一个前景广阔的解决方案来自一个不太可能的来源--丰富的生物聚合物木质素
智取真菌入侵者病原体如何劫持我们的免疫防御系统
真菌对人类健康的主要威胁常常被忽视,而细菌和病毒感染所造成的巨大影响则使其黯然失色。然而,这些真核微生物却构成了日益严重的威胁,每年造成全球数百万人死亡。而它们的成功在很大程度上是因为它们有能力操纵我们赖以保持健康的免疫防御系统。
为干旱世界解渴:紧凑型燃料动力大气集水器
随着全球人口的不断激增和气候变化对传统水源的破坏,对淡水生产创新方法的需求从未像现在这样迫切。现在,一种前景广阔的解决方案已经出现,那就是基于吸附技术的大气集水(SAWH)装置
社论
去探险
活动 | 揭开伦敦扭曲博物馆的神秘面纱
扭转博物馆(Twist Museum)坐落于伦敦市中心,是意外艺术的杰出见证。凭借其引人入胜的展品和发人深省的装置,这块隐藏的瑰宝为游客带来了独一无二的难忘体验。
活动 | 伟大的展览路艺术节:科学、艺术和创新的庆典
大展览路节是每年夏天在南肯辛顿举办的免费科学和艺术庆祝活动。2024 年 6 月,我们将在周末为所有年龄段的人们举办免费的科学和艺术活动。您可以参加由标志性博物馆、研究和文化机构举办的动手工作坊、精彩讲座、表演和装置艺术活动。
活动 | 探索奇迹与发现:曼彻斯特科学与工业博物馆之旅
位于曼彻斯特的科学与工业博物馆(Science and Industry Museum)是一个吸引人的旅游景点,为儿童和成人提供了丰富多彩的展品和活动。该博物馆致力于培养好奇心、创新精神和学习能力,是通向科学奇迹和工业历史奇迹的大门。
活动 | 探索奇迹与发现:曼彻斯特科学与工业博物馆之旅
位于曼彻斯特的科学与工业博物馆(Science and Industry Museum)是一个吸引人的旅游景点,为儿童和成人提供了丰富多彩的展品和活动。该博物馆致力于培养好奇心、创新精神和学习能力,是通向科学奇迹和工业历史奇迹的大门。
活动 | 伟大的展览路艺术节:科学、艺术和创新的庆典
大展览路节是每年夏天在南肯辛顿举办的免费科学和艺术庆祝活动。2024 年 6 月,我们将在周末为所有年龄段的人们举办免费的科学和艺术活动。您可以参加由标志性博物馆、研究和文化机构举办的动手工作坊、精彩讲座、表演和装置艺术活动。
活动 | 天琴座流星雨:四月的天空奇观
在浩瀚无垠的夜空中,一场迷人的天象正在等待着天文爱好者和观星者。准备好迎接天琴座流星雨吧!每年四月中下旬,天琴座流星雨都会上演一场炫目的流星表演。
活动 | 揭开伦敦扭曲博物馆的神秘面纱
扭转博物馆(Twist Museum)坐落于伦敦市中心,是意外艺术的杰出见证。凭借其引人入胜的展品和发人深省的装置,这块隐藏的瑰宝为游客带来了独一无二的难忘体验。
FlyWire is a human-AI collaboration for reconstructing the full brain connectome of Drosophila. It is made possible by contributions from hundreds of scientists around the globe. The potential benefits of such a resource are immense – we can now make significant advances in our understanding of how the brain works by ultimately linking neuronal wiring with brain function.
人工智能领域的最新成果
人工智能领域的最新成果
来自其他网站
科学
- Single-dose baloxavir reduces household influenza...on April, 2025 at 3:38 pm
A landmark study reveals that a single oral dose of baloxavir marboxil (baloxavir) significantly reduces the transmission of influenza within households, marking a major advancement in influenza management. The trial provides robust evidence that an antiviral treatment can curb the spread of […]
技术
- Physicists uncover hidden order in the quantum...on April, 2025 at 3:38 pm
A recent study has unraveled some of the secrets concealed within the entangled web of quantum systems.
制药
- Structure dictates effectiveness, safety in...on April, 2025 at 3:34 pm
Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue this precise control should be applied to optimize new nanomedicines.
健康
- Are 'zombie' skin cells harmful or helpful? The...on April, 2025 at 6:38 pm
Researchers have identified three subtypes of senescent skin cells with distinct shapes, biomarkers, and functions -- an advance that could equip scientists with the ability to target and kill the harmful types while leaving the helpful ones intact.
HEADER IMAGE | A solitary boy sits amidst urban destruction as monstrous storms wreak havoc in a nightmarish scene brought on by the relentless rise in global temperatures. Are we being over dramatic? We think not. The time to be polite regarding the topic has passed. ADOBE STOCK #1068157517