PHARMA
Stability Oracle: A Powerful Tool for Engineering Stable Proteins
In the rapidly evolving world of biotechnology, the ability to engineer proteins with enhanced stability is a critical challenge. Computational methods that can accurately predict how amino acid mutations will impact a protein's thermodynamic stability could revolutionize the protein engineering process. Enter Stability Oracle, a new deep learning framework that outperforms state-of-the-art methods in predicting thermodynamically stabilizing protein mutations
A New Era in US Schizophrenia Treatment: The FDA Approval of COBENFY
In a significant development for the field of neuropsychiatry, the U.S. Food and Drug Administration (FDA) has granted approval for COBENFY™ (xanomeline and trospium chloride), marking the introduction of the first new pharmacological approach to treating schizophrenia in decades
The Rise and Fall of Oxbryta: A Cautionary Tale in Sickle Cell Disease Treatment
The landscape of medical treatments for chronic illnesses is often marked by innovation, hope, and occasionally, disappointment. One such instance is the recent announcement by Pfizer to withdraw its sickle cell disease treatment, Oxbryta (voxelotor), from all markets where it was approved
The Evolving ABPI Code: Strengthening Ethical Standards in the Pharmaceutical Industry?
In the rapidly evolving landscape of the pharmaceutical industry, does the updated 2024 ABPI (Association of the British Pharmaceutical Industry) Code of Practice represent a significant step forward in raising the bar for ethical and transparent practices?
Blockchain Revolutionizing the Pharmaceutical Industry: Ensuring Transparency, Security and Efficiency
Blockchain technology has emerged as a game-changer in various sectors, and the pharmaceutical industry is no exception. With its decentralized and transparent nature, blockchain holds tremendous potential to revolutionize drug development, supply chain management, clinical trials, and patient data security
HEALTH
Rethinking Suicide Prevention: A Public Health Approach to a Global Problem
Suicide is a major public health crisis, claiming over 700,000 lives globally each year. Yet, despite its staggering toll, suicide is a preventable tragedy. A new framework is emerging that could transform how we approach this complex issue - by shifting the focus from individual-level risk factors to the broader social determinants that shape suicide risk across populations
Outwitting the Fungal Invaders: How Pathogens Hijack Our Immune Defenses
Fungi are often overlooked as a major threat to human health, overshadowed by the more dramatic impacts of bacterial and viral infections. Yet these eukaryotic microbes pose a serious and growing danger, responsible for millions of deaths worldwide each year. And their success is largely due to their ability to manipulate the very immune defenses we rely on to keep us healthy.
The NHS at a Crossroads: Restoring Britain’s National Health Service
The National Health Service (NHS) finds itself in a state of crisis, struggling with long waiting times, declining quality of care, and a growing gap between service demands and available resources. As the independent investigation led by Lord Darzi has revealed, the roots of this crisis run deep, stemming from a decade of austerity, the devastating impact of the COVID-19 pandemic, short sighted policy implementations and longstanding structural and systemic issues within the health service.
SCIENCE, TECHNOLOGY
Stability Oracle: A Powerful Tool for Engineering Stable Proteins
In the rapidly evolving world of biotechnology, the ability to engineer proteins with enhanced stability is a critical challenge. Computational methods that can accurately predict how amino acid mutations will impact a protein's thermodynamic stability could revolutionize the protein engineering process. Enter Stability Oracle, a new deep learning framework that outperforms state-of-the-art methods in predicting thermodynamically stabilizing protein mutations
Buried Treasure: How Martian Clays Could Unlock the Planet’s Mysterious Past
The early Martian atmosphere was once flush with carbon dioxide, but over time this thick atmosphere thinned dramatically. Where did all that carbon go? The answer may lie in the very rocks and minerals that coat the Martian surface
Turning Lignin into Jet Fuel: A Sustainable Aviation Breakthrough
As the global aviation industry strives to reduce its environmental impact, the race is on to develop sustainable aviation fuels (SAFs) that can replace traditional petroleum-based jet fuel. One promising solution lies in an unlikely source - the abundant biopolymer lignin
Outwitting the Fungal Invaders: How Pathogens Hijack Our Immune Defenses
Fungi are often overlooked as a major threat to human health, overshadowed by the more dramatic impacts of bacterial and viral infections. Yet these eukaryotic microbes pose a serious and growing danger, responsible for millions of deaths worldwide each year. And their success is largely due to their ability to manipulate the very immune defenses we rely on to keep us healthy.
Quenching the Thirst of the Arid World: Compact Fuel-Powered Atmospheric Water Harvesters
As the global population continues to surge and climate change disrupts traditional water sources, the need for innovative approaches to freshwater production has never been more pressing. Now a promising solution has emerged in the form of sorption-based atmospheric water harvesting (SAWH) devices
Autonomous vs Human-Driven Vehicle Accidents: What the Data Reveals
A new study published in Nature Communications provides a detailed comparative analysis of accidents involving AVs versus human-driven vehicles (HDVs). Researchers Mohamed Abdel-Aty and Shengxuan Ding, from the University of Central Florida, utilized a dataset of over 37,000 accidents to uncover the differential characteristics and risk factors between the two vehicle types.
A Single Therapy for Asthma: Engineering Long-Lived T Cells with Multi-Targeting Abilities
Researchers at Tsinghua University in Beijing may have found an alternative approach that could push severe asthma into long-term remission with just a single treatment: engineering long-lived T cells with the unique ability to target multiple drivers of the condition simultaneously.
Weaving Electronics into Living Systems
From smartphones to smart homes, digital devices have become deeply intertwined with how we work, play, and interact with the world. What if these electronics could form imperceptible bonds with skin, plants, and other biological materials? A team of researchers from the University of Cambridge may have found an innovative way to do just that.
Hidden Dangers Under Antarctic Ice
Satellite Radar Reveals Extensive Seawater Intrusions Beneath Thwaites Glacier. This may explain why the rate of glacial loss has been greater than expected from modelling
EDITORIAL
GO EXPLORING
ACTIVITY | The Great Exhibition Road Festival: A Celebration of Science, Art, and Innovation
The Great Exhibition Road Festival is a free annual celebration of science and the arts each summer in South Kensington. Join us in June 2024 for a weekend of free science and arts events for all ages. Enjoy hands-on workshops, fascinating talks, performances and installations from iconic museums, research and culture organisations
ACTIVITY | Exploring the Wonders of Kew Gardens: A Paradise for Young Explorers
Nestled in the heart of London, Kew Gardens is a remarkable botanical paradise that captivates visitors of all ages. While its beauty and scientific significance are widely acclaimed, Kew Gardens holds a special allure for children, offering a myriad of exciting activities and educational opportunities
ACTIVITY | Unraveling the Marvels of the Twist Museum in London
Nestled in the heart of London, the Twist Museum stands as a remarkable testament to the art of the unexpected. With its captivating exhibits and thought-provoking installations, this hidden gem offers visitors a unique and memorable experience like no other
ACTIVITY | The Lyrid Meteor Shower: An April Sky Spectacle
In the vast expanse of the night sky, a captivating celestial event awaits astronomy enthusiasts and stargazers alike. Brace yourselves for the Lyrid meteor shower, a dazzling display of shooting stars that occurs annually in mid to late April.
ACTIVITY | Unraveling the Marvels of the Twist Museum in London
Nestled in the heart of London, the Twist Museum stands as a remarkable testament to the art of the unexpected. With its captivating exhibits and thought-provoking installations, this hidden gem offers visitors a unique and memorable experience like no other
ACTIVITY | The Great Exhibition Road Festival: A Celebration of Science, Art, and Innovation
The Great Exhibition Road Festival is a free annual celebration of science and the arts each summer in South Kensington. Join us in June 2024 for a weekend of free science and arts events for all ages. Enjoy hands-on workshops, fascinating talks, performances and installations from iconic museums, research and culture organisations
ACTIVITY | Exploring the Wonders of Kew Gardens: A Paradise for Young Explorers
Nestled in the heart of London, Kew Gardens is a remarkable botanical paradise that captivates visitors of all ages. While its beauty and scientific significance are widely acclaimed, Kew Gardens holds a special allure for children, offering a myriad of exciting activities and educational opportunities
ACTIVITY | Exploring Wonder and Discovery: A Journey Through the Science and Industry Museum in Manchester
The Science and Industry Museum in Manchester is a captivating destination that offers a wide array of exhibits and activities for both children and adults. With its commitment to fostering curiosity, innovation, and learning, the museum stands as a gateway to the wonders of science and the marvels of industrial history
After 11 years, Boston Dynamics has said goodbye to its humanoid robot ATLAS HD. The robotics company says it’s time for ATLAS to “kick back and relax” in retirement, letting the new all electric ATLAS take over. This video was shared to remember ATLAS HD’s great moments and those not so great.
LATEST WITHIN ARTIFICAL INTELLIGENCE
LATEST WITHIN ARTIFICAL INTELLIGENCE
FROM ELSEWHERE ON THE WEB
Science
- As temperatures rise, researchers identify...on October, 2024 at 7:40 pm
Plants widen microscopic pores on their leaves in response to heat. But scientists lacked an understanding of the mechanisms behind this 'sweating' function. Now, biologists have unlocked the details behind these processes and identified two paths that plants use to handle rising temperatures.
Technology
- New theory demystifies crystallization processon October, 2024 at 8:56 pm
A new theory 'demystifies' the crystallization process and shows that the material that crystallizes is the dominant component within a solution -- which is the solvent, not the solute. The theory could have implications for everything from drug development to understanding climate change.
Pharma
- Seeing double: Designing drugs that target 'twin'...on October, 2024 at 7:29 pm
Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites. To design a drug that blocks a cancer-related protein, […]
Health
- Unpacking polar sea iceon October, 2024 at 10:09 pm
University of Utah mathematics and climate researchers are building new models for understanding the dynamics of sea ice, which is not as solid as you might think.
HEADER IMAGE | On September 30th the UK finished with coal power after 142 years. The UK stopped producing any electricity from burning coal – ending its 142-year reliance on the fossil fuel. The country’s last coal power station, at Ratcliffe-on-Soar, finished operations on Monday the 30th of September after running since 1967. The image is not of that coal station. ADOBE STOCK File #: 1002917027