In the rapidly evolving world of biotechnology, the ability to engineer proteins with enhanced stability is a critical challenge. Computational methods that can accurately predict how amino acid mutations will impact a protein’s thermodynamic stability could revolutionize the protein engineering process. Enter Stability Oracle, a new deep learning framework that outperforms state-of-the-art methods in predicting thermodynamically stabilizing protein mutations
In the rapidly evolving world of biotechnology, the ability to engineer proteins with enhanced stability is a critical challenge. Computational methods that can accurately predict how amino acid mutations will impact a protein's thermodynamic stability could revolutionize the protein engineering process. Enter Stability Oracle, a new deep learning framework that outperforms state-of-the-art methods in predicting thermodynamically stabilizing protein mutations
In a significant development for the field of neuropsychiatry, the U.S. Food and Drug Administration (FDA) has granted approval for COBENFY™ (xanomeline and trospium chloride), marking the introduction of the first new pharmacological approach to treating schizophrenia in decades
The landscape of medical treatments for chronic illnesses is often marked by innovation, hope, and occasionally, disappointment. One such instance is the recent announcement by Pfizer to withdraw its sickle cell disease treatment, Oxbryta (voxelotor), from all markets where it was approved
In the rapidly evolving landscape of the pharmaceutical industry, does the updated 2024 ABPI (Association of the British Pharmaceutical Industry) Code of Practice represent a significant step forward in raising the bar for ethical and transparent practices?
Blockchain technology has emerged as a game-changer in various sectors, and the pharmaceutical industry is no exception. With its decentralized and transparent nature, blockchain holds tremendous potential to revolutionize drug development, supply chain management, clinical trials, and patient data security
The Life Sciences sector now finds itself facing intensifying global competition, with other nations aggressively courting the industry's prized assets and expertise. Meanwhile, the National Health Service (NHS) has grappled with the dual challenge of constrained budgets and the rising costs of newer, more innovative medicines
In the highly competitive pharmaceutical industry, companies must carefully navigate the complex regulatory landscape when promoting their products. A recent case ruling by the Prescription Medicines Code of Practice Authority (PMCPA) highlights the importance of ensuring promotional claims are accurate, balanced and supported by robust evidence.
Over a decade since the first clinical trials began, long-term follow-up data have affirmed CAR T-cells’ ability to induce durable remissions in certain patients. However, the therapy also faces challenges, as not all treated cancers respond equally well and toxicity remains a concern. Ongoing research aims to optimize various aspects of CAR T-cell treatment to improve outcomes on a broader scale.
Researchers at Creighton University may have discovered a new use for the antiviral Oseltamivir (Tamiflu) that could help many more people at risk of hearing impairment.
Antibody-based therapies have transformed cancer treatment over the past few decades. A recent review published in Nature Reviews Cancer provides a comprehensive overview of the progress made to date and the exciting new frontiers on the horizon
When a quantum computer processes data, it must translate it into understandable quantum data. Algorithms that carry out this 'quantum compilation' typically optimize one target at a time. However, a team has created an algorithm capable of optimizing multiple targets at once, effectively enabling […]
Nanostructured two-dimensional gold monolayers offer possibilities in catalysis, electronics, and nanotechnology.
A groundbreaking piece of navigation technology that uses the ability to sense information through touch can help people with visual impairment perform a location task as well as sighted people, according to new research.
For human researchers, it takes many years of work to discover new super-resolution microscopy techniques. The number of possible optical configurations of a microscope -- for example, where to place mirrors or lenses -- is enormous. Researchers have now developed an artificial intelligence (AI) […]
Using microparticles consisting of extremely thin petals, medicines can be delivered via the bloodstream in a precisely targeted manner, for example to a tumour or blood clot. Ultrasound and other acoustic procedures guide the particles through the body and reveal their locations. This makes the […]
After 11 years, Boston Dynamics has said goodbye to its humanoid robot ATLAS HD. The robotics company says it’s time for ATLAS to “kick back and relax” in retirement, letting the new all electric ATLAS take over. This video was shared to remember ATLAS HD’s great moments and those not so great.
Header Banner: AZT the development name for zidovudine was the first drug launched to treat HIV. It was used in high doses and as monotherapy, causing horrendous side effects and resistance in the HIV virus. In the subsequent 30 years clinical trials has led to the development of single tablet, once daily regimens to treat HIV with limited side effects. Now a two pill combination called Truvada can be given to individuals to prevent the risk of acquiring HIV (shown in the DarkDrug logo).
