The ENRICH trial, published in The Lancet in October 2025, delivers the first large randomized test of a chemotherapy‑free front‑line strategy for this population. It compares the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib combined with the anti‑CD20 antibody rituximab against standard immunochemotherapy.
The ENRICH trial, published in The Lancet in October 2025, delivers the first large randomized test of a chemotherapy‑free front‑line strategy for this population. It compares the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib combined with the anti‑CD20 antibody rituximab against standard immunochemotherapy.
Snakebite envenoming poses a persistent threat to public health. The World Health Organization recognizes it as a neglected tropical disease, responsible for over 100,000 deaths annually and leaving another 300,000 individuals with permanent disabilities.In groundbreaking research, scientists have turned to de novo designed proteins as a novel approach to counteract these venom toxins. Using deep learning methods, researchers have successfully created protein designs that demonstrate potential as next-generation antivenom therapeutics.
In the realm of cellular biology, senescence has emerged as a pivotal process influencing both the progression of cancer and the onset of age-related diseases. Defined as a state where cells cease to divide but remain metabolically active, senescence acts as a double-edged sword. Key life sciences companies are pinning pipeline hopes in cracking this.
In the face of a rapidly changing climate, the concept of hydroclimate volatility has emerged as a critical area of study, highlighting the dramatic and often sudden fluctuations between extremely dry and wet conditions. This phenomenon poses significant challenges to both natural ecosystems and human societies
In the ever-evolving landscape of pharmaceutical marketing, the industry faces a delicate balance between informing the public and adhering to strict regulations. This challenge was thrust into the spotlight with the recent case of CSL Seqirus and the alleged promotion of their prescription-only Flucelvax Influenza vaccine on the social media platform LinkedIn.
We write to you today with a profound sense of alarm and a pressing need for urgent action. The events unfolding in the Antarctic are a stark harbinger of the dangers posed by climate change, and they demand an immediate and concerted global response.
The recently launched Lancet Commission on Racism and Child Health has embarked on a pioneering journey to unravel the profound impact of racism, xenophobia, and discrimination on child health worldwide. This editorial delves into the multifaceted dimensions of this issue, exploring the pathways through which racism affects health outcomes and highlighting the urgent need for systemic change.
عكف سيونغ ومورثي على تطوير خريطة FlyWire لأكثر من أربع سنوات، باستخدام صور الفحص المجهري الإلكتروني لشرائح من دماغ الذبابة. قام الباحثان ومئات من زملائهم العالميين بتجميع البيانات معًا لتشكيل خريطة كاملة للدماغ بمساعدة أدوات الذكاء الاصطناعي. يعد هذا إنجازاً هائلاً ويحدث بالفعل ثورة في هذا المجال.
في عالم التكنولوجيا الحيوية سريع التطور، تمثل القدرة على هندسة البروتينات ذات الثبات المعزز تحديًا بالغ الأهمية. يمكن للطرق الحسابية التي يمكنها التنبؤ بدقة بكيفية تأثير طفرات الأحماض الأمينية على الاستقرار الديناميكي الحراري للبروتين أن تحدث ثورة في عملية هندسة البروتين. ندخل إلى أوراكل الاستقرار، وهو إطار عمل جديد للتعلم العميق يتفوق على أحدث الأساليب في التنبؤ بطفرات البروتين التي تعمل على استقرار البروتين من الناحية الديناميكية الحرارية
كان الغلاف الجوي للمريخ في وقت مبكر مليئاً بثاني أكسيد الكربون، لكن بمرور الوقت ضعف هذا الغلاف الجوي السميك بشكل كبير. أين ذهب كل هذا الكربون؟ قد تكمن الإجابة في نفس الصخور والمعادن التي تغطي سطح المريخ
Astronomers have revealed new research showing that millions of new solar system objects are likely to be detected by a brand-new facility, which is expected to come online later this year.
New research demonstrates that with collaboration between stakeholders, Australia can fully decarbonize its domestic and energy export economies by 2060 -- a feat requiring $6.2 trillion USD and around 110,000 square kilomters of land -- while avoiding harm to important areas for biodiversity […]
The effects of artificial intelligence on adolescents are nuanced and complex, according to a new report that calls on developers to prioritize features that protect young people from exploitation, manipulation and the erosion of real-world relationships.
A new study found exposure to specific tiny particles in air pollution during pregnancy are associated with increased risk of various negative birth outcomes.
A new study details processes that keep pollutants aloft despite a drop in emissions.
بعد 11 عاماً، ودّعت شركة Boston Dynamics روبوتها الروبوت ATLAS HD. تقول شركة الروبوتات إن الوقت قد حان لـ ATLAS "للراحة والاسترخاء" في التقاعد، والسماح للروبوت الجديد ATLAS الكهربائي بالكامل بتولي المسؤولية. تمت مشاركة هذا الفيديو لتذكر لحظات أطلس HD الرائعة وتلك غير الرائعة.
