The ENRICH trial, published in The Lancet in October 2025, delivers the first large randomized test of a chemotherapy‑free front‑line strategy for this population. It compares the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib combined with the anti‑CD20 antibody rituximab against standard immunochemotherapy.
The ENRICH trial, published in The Lancet in October 2025, delivers the first large randomized test of a chemotherapy‑free front‑line strategy for this population. It compares the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib combined with the anti‑CD20 antibody rituximab against standard immunochemotherapy.
Snakebite envenoming poses a persistent threat to public health. The World Health Organization recognizes it as a neglected tropical disease, responsible for over 100,000 deaths annually and leaving another 300,000 individuals with permanent disabilities.In groundbreaking research, scientists have turned to de novo designed proteins as a novel approach to counteract these venom toxins. Using deep learning methods, researchers have successfully created protein designs that demonstrate potential as next-generation antivenom therapeutics.
In the realm of cellular biology, senescence has emerged as a pivotal process influencing both the progression of cancer and the onset of age-related diseases. Defined as a state where cells cease to divide but remain metabolically active, senescence acts as a double-edged sword. Key life sciences companies are pinning pipeline hopes in cracking this.
In the face of a rapidly changing climate, the concept of hydroclimate volatility has emerged as a critical area of study, highlighting the dramatic and often sudden fluctuations between extremely dry and wet conditions. This phenomenon poses significant challenges to both natural ecosystems and human societies
In the ever-evolving landscape of pharmaceutical marketing, the industry faces a delicate balance between informing the public and adhering to strict regulations. This challenge was thrust into the spotlight with the recent case of CSL Seqirus and the alleged promotion of their prescription-only Flucelvax Influenza vaccine on the social media platform LinkedIn.
We write to you today with a profound sense of alarm and a pressing need for urgent action. The events unfolding in the Antarctic are a stark harbinger of the dangers posed by climate change, and they demand an immediate and concerted global response.
The recently launched Lancet Commission on Racism and Child Health has embarked on a pioneering journey to unravel the profound impact of racism, xenophobia, and discrimination on child health worldwide. This editorial delves into the multifaceted dimensions of this issue, exploring the pathways through which racism affects health outcomes and highlighting the urgent need for systemic change.
Seung 和 Murthy 利用电子显微镜拍摄的苍蝇大脑切片图像，开发 FlyWire 地图已有四年多时间。在人工智能（AI）工具的帮助下，研究人员及其数百名全球同事将数据拼接在一起，形成了完整的大脑地图。这是一项巨大的成就，已经在该领域掀起了一场革命。
在飞速发展的生物技术领域，能否设计出稳定性更强的蛋白质是一项严峻的挑战。能够准确预测氨基酸突变将如何影响蛋白质热力学稳定性的计算方法将彻底改变蛋白质工程过程。 Stability Oracle 是一种新的深度学习框架，在预测热力学稳定蛋白质突变方面优于最先进的方法。
早期的火星大气层曾经充满二氧化碳，但随着时间的推移，这种浓厚的大气层急剧变薄。这些碳都去哪儿了呢？答案可能就在覆盖在火星表面的岩石和矿物中
Astronomers have revealed new research showing that millions of new solar system objects are likely to be detected by a brand-new facility, which is expected to come online later this year.
New research demonstrates that with collaboration between stakeholders, Australia can fully decarbonize its domestic and energy export economies by 2060 -- a feat requiring $6.2 trillion USD and around 110,000 square kilomters of land -- while avoiding harm to important areas for biodiversity […]
The effects of artificial intelligence on adolescents are nuanced and complex, according to a new report that calls on developers to prioritize features that protect young people from exploitation, manipulation and the erosion of real-world relationships.
A new study found exposure to specific tiny particles in air pollution during pregnancy are associated with increased risk of various negative birth outcomes.
A new study details processes that keep pollutants aloft despite a drop in emissions.
11 年后，波士顿动力公司（Boston Dynamics）与其仿人机器人 ATLAS HD 说再见了。这家机器人公司表示，现在是 ATLAS 退休 "休息放松 "的时候了，新的全电动 ATLAS 将接替它的工作。分享这段视频是为了纪念 ATLAS HD 的伟大时刻和那些不那么伟大的时刻。
