The ENRICH trial, published in The Lancet in October 2025, delivers the first large randomized test of a chemotherapy‑free front‑line strategy for this population. It compares the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib combined with the anti‑CD20 antibody rituximab against standard immunochemotherapy.
The ENRICH trial, published in The Lancet in October 2025, delivers the first large randomized test of a chemotherapy‑free front‑line strategy for this population. It compares the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib combined with the anti‑CD20 antibody rituximab against standard immunochemotherapy.
Snakebite envenoming poses a persistent threat to public health. The World Health Organization recognizes it as a neglected tropical disease, responsible for over 100,000 deaths annually and leaving another 300,000 individuals with permanent disabilities.In groundbreaking research, scientists have turned to de novo designed proteins as a novel approach to counteract these venom toxins. Using deep learning methods, researchers have successfully created protein designs that demonstrate potential as next-generation antivenom therapeutics.
In the realm of cellular biology, senescence has emerged as a pivotal process influencing both the progression of cancer and the onset of age-related diseases. Defined as a state where cells cease to divide but remain metabolically active, senescence acts as a double-edged sword. Key life sciences companies are pinning pipeline hopes in cracking this.
In the face of a rapidly changing climate, the concept of hydroclimate volatility has emerged as a critical area of study, highlighting the dramatic and often sudden fluctuations between extremely dry and wet conditions. This phenomenon poses significant challenges to both natural ecosystems and human societies
In the ever-evolving landscape of pharmaceutical marketing, the industry faces a delicate balance between informing the public and adhering to strict regulations. This challenge was thrust into the spotlight with the recent case of CSL Seqirus and the alleged promotion of their prescription-only Flucelvax Influenza vaccine on the social media platform LinkedIn.
We write to you today with a profound sense of alarm and a pressing need for urgent action. The events unfolding in the Antarctic are a stark harbinger of the dangers posed by climate change, and they demand an immediate and concerted global response.
The recently launched Lancet Commission on Racism and Child Health has embarked on a pioneering journey to unravel the profound impact of racism, xenophobia, and discrimination on child health worldwide. This editorial delves into the multifaceted dimensions of this issue, exploring the pathways through which racism affects health outcomes and highlighting the urgent need for systemic change.
सेउंग और मूर्ति चार साल से अधिक समय से फ्लाईवायर मानचित्र विकसित कर रहे हैं, जिसमें मक्खी के मस्तिष्क के टुकड़ों की इलेक्ट्रॉन माइक्रोस्कोपी छवियों का उपयोग किया गया है। शोधकर्ताओं और उनके सैकड़ों वैश्विक सहयोगियों ने कृत्रिम-बुद्धि (एआई) उपकरणों की मदद से मस्तिष्क का पूरा मानचित्र बनाने के लिए डेटा को एक साथ जोड़ा। यह एक बहुत बड़ी उपलब्धि है और पहले से ही इस क्षेत्र में क्रांति ला रही है।
जैव प्रौद्योगिकी की तेजी से विकसित होती दुनिया में, बढ़ी हुई स्थिरता वाले प्रोटीन को इंजीनियर करने की क्षमता एक महत्वपूर्ण चुनौती है। कम्प्यूटेशनल विधियाँ जो सटीक रूप से भविष्यवाणी कर सकती हैं कि अमीनो एसिड उत्परिवर्तन प्रोटीन की थर्मोडायनामिक स्थिरता को कैसे प्रभावित करेंगे, प्रोटीन इंजीनियरिंग प्रक्रिया में क्रांतिकारी बदलाव ला सकती हैं। स्टेबिलिटी ऑरेकल, एक नया डीप लर्निंग फ्रेमवर्क जो थर्मोडायनामिक रूप से स्थिर प्रोटीन उत्परिवर्तन की भविष्यवाणी करने में अत्याधुनिक विधियों से बेहतर प्रदर्शन करता है
मंगल ग्रह का आरंभिक वायुमंडल कार्बन डाइऑक्साइड से भरा हुआ था, लेकिन समय के साथ यह घना वायुमंडल नाटकीय रूप से पतला हो गया। वह सारा कार्बन कहां गया? इसका उत्तर संभवतः उन चट्टानों और खनिजों में छिपा है जो मंगल ग्रह की सतह पर मौजूद हैं
Astronomers have revealed new research showing that millions of new solar system objects are likely to be detected by a brand-new facility, which is expected to come online later this year.
New research demonstrates that with collaboration between stakeholders, Australia can fully decarbonize its domestic and energy export economies by 2060 -- a feat requiring $6.2 trillion USD and around 110,000 square kilomters of land -- while avoiding harm to important areas for biodiversity […]
The effects of artificial intelligence on adolescents are nuanced and complex, according to a new report that calls on developers to prioritize features that protect young people from exploitation, manipulation and the erosion of real-world relationships.
A new study found exposure to specific tiny particles in air pollution during pregnancy are associated with increased risk of various negative birth outcomes.
A new study details processes that keep pollutants aloft despite a drop in emissions.
11 साल बाद, बोस्टन डायनेमिक्स ने अपने ह्यूमनॉइड रोबोट एटलस एचडी को अलविदा कह दिया है। रोबोटिक्स कंपनी का कहना है कि अब एटलस के लिए रिटायरमेंट में "आराम करने और आराम करने" का समय आ गया है, ताकि नए ऑल इलेक्ट्रिक एटलस को कमान सौंपी जा सके। यह वीडियो एटलस एचडी के बेहतरीन पलों और उन पलों को याद करने के लिए शेयर किया गया है जो इतने शानदार नहीं थे।
