Snakebite envenoming poses a persistent threat to public health. The World Health Organization recognizes it as a neglected tropical disease, responsible for over 100,000 deaths annually and leaving another 300,000 individuals with permanent disabilities.In groundbreaking research, scientists have turned to de novo designed proteins as a novel approach to counteract these venom toxins. Using deep learning methods, researchers have successfully created protein designs that demonstrate potential as next-generation antivenom therapeutics.
Dilruwan Herath
Revolutionizing Antivenom: The Quest to Neutralize Snake Venom with De Novo AI Designed Proteins
Snakebite envenoming poses a persistent threat to public health. The World Health Organization recognizes it as a neglected tropical disease, responsible for over 100,000 deaths annually and leaving another 300,000 individuals with permanent disabilities.In groundbreaking research, scientists have turned to de novo designed proteins as a novel approach to counteract these venom toxins. Using deep learning methods, researchers have successfully created protein designs that demonstrate potential as next-generation antivenom therapeutics.
Targeting Cellular Senescence: A New Frontier in Combating Cancer and Age-Related Diseases
In the realm of cellular biology, senescence has emerged as a pivotal process influencing both the progression of cancer and the onset of age-related diseases. Defined as a state where cells cease to divide but remain metabolically active, senescence acts as a double-edged sword. Key life sciences companies are pinning pipeline hopes in cracking this.
Hydroclimate Volatility: Navigating Extremes on a Warming Earth
In the face of a rapidly changing climate, the concept of hydroclimate volatility has emerged as a critical area of study, highlighting the dramatic and often sudden fluctuations between extremely dry and wet conditions. This phenomenon poses significant challenges to both natural ecosystems and human societies
Navigating the New Frontier: The First Abridged Complaint under the 2024 ABPI Code
In the ever-evolving landscape of pharmaceutical marketing, the industry faces a delicate balance between informing the public and adhering to strict regulations. This challenge was thrust into the spotlight with the recent case of CSL Seqirus and the alleged promotion of their prescription-only Flucelvax Influenza vaccine on the social media platform LinkedIn.
Dear World Leaders, A Clarion Call to Action: Addressing the Peril of Antarctic Sea Ice Loss
We write to you today with a profound sense of alarm and a pressing need for urgent action. The events unfolding in the Antarctic are a stark harbinger of the dangers posed by climate change, and they demand an immediate and concerted global response.
Unveiling Injustice: The Imperative of Addressing Racism in Global Child Health
The recently launched Lancet Commission on Racism and Child Health has embarked on a pioneering journey to unravel the profound impact of racism, xenophobia, and discrimination on child health worldwide. This editorial delves into the multifaceted dimensions of this issue, exploring the pathways through which racism affects health outcomes and highlighting the urgent need for systemic change.
La conquista del conectoma: La cartografía de los secretos del cerebro
Seung y Murthy llevan más de cuatro años desarrollando el mapa FlyWire a partir de imágenes de microscopía electrónica de cortes del cerebro de la mosca. Los investigadores y sus cientos de colegas de todo el mundo unieron los datos para formar un mapa completo del cerebro con ayuda de herramientas de inteligencia artificial (IA). Se trata de un logro inmenso que ya está revolucionando este campo.
Oráculo de estabilidad: Una potente herramienta para diseñar proteínas estables
En el mundo de la biotecnología, en rápida evolución, la capacidad de diseñar proteínas con mayor estabilidad es un reto crucial. Los métodos computacionales capaces de predecir con exactitud cómo afectarán las mutaciones de aminoácidos a la estabilidad termodinámica de una proteína podrían revolucionar el proceso de ingeniería de proteínas. Stability Oracle es un nuevo marco de aprendizaje profundo que supera a los métodos más avanzados en la predicción de mutaciones de proteínas termodinámicamente estabilizadoras.
Un tesoro enterrado: cómo las arcillas marcianas podrían desvelar el misterioso pasado del planeta
La atmósfera marciana primitiva estaba repleta de dióxido de carbono, pero con el tiempo esta espesa atmósfera se redujo drásticamente. ¿Adónde fue a parar todo ese carbono? La respuesta puede estar en las rocas y minerales que recubren la superficie marciana.
Transformar la lignina en combustible para aviones: un avance sostenible para la aviación
La industria mundial de la aviación se esfuerza por reducir su impacto ambiental, por lo que ha comenzado la carrera para desarrollar combustibles de aviación sostenibles (SAF) que puedan sustituir al tradicional combustible de aviación derivado del petróleo. Una solución prometedora reside en una fuente poco probable: el abundante biopolímero lignina.
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Researchers have used machine learning to design nano-architected materials that have the strength of carbon steel but the lightness of Styrofoam. The team describes how they made nanomaterials with properties that offer a conflicting combination of exceptional strength, light weight and […]
- Peeling back the layers: Exploring capping...on January, 2025 at 8:14 pm
Researchers used cutting-edge X-ray techniques to gain new insights into 'infinite-layer' nickelate materials.
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A research team has made significant discoveries regarding the complex reaction mechanisms of carbon dioxide (CO2) in supercritical water. These findings are crucial for understanding the molecular mechanisms of CO2 mineralization and sequestration in nature and engineering, as well as the deep […]
- Quantum: Calculating error-free more easily with...on January, 2025 at 8:12 pm
Various methods are used to correct errors in quantum computers. Not all operations can be implemented equally well with different correction codes. Therefore, a research team has developed a method and implemented it experimentally for the first time, with which a quantum computer can switch back […]
- Revolutionizing ammonia synthesis: New iron-based...on January, 2025 at 8:12 pm
The novel iron-based catalyst exhibits superior performance for ammonia (NH3) synthesis compared to a well-established, century-old counterpart. By designing this new catalyst with an inverse structure, they managed to boost the NH3 production rate per volume of catalyst beyond levels never reached […]
Después de 11 años, Boston Dynamics ha dicho adiós a su robot humanoide ATLAS HD. La empresa de robótica afirma que ha llegado el momento de que ATLAS se jubile y deje paso al nuevo ATLAS eléctrico. Este vídeo se ha compartido para recordar los grandes momentos de ATLAS HD y los no tan grandes.