The ENRICH trial, published in The Lancet in October 2025, delivers the first large randomized test of a chemotherapy‑free front‑line strategy for this population. It compares the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib combined with the anti‑CD20 antibody rituximab against standard immunochemotherapy.
The ENRICH trial, published in The Lancet in October 2025, delivers the first large randomized test of a chemotherapy‑free front‑line strategy for this population. It compares the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib combined with the anti‑CD20 antibody rituximab against standard immunochemotherapy.
Snakebite envenoming poses a persistent threat to public health. The World Health Organization recognizes it as a neglected tropical disease, responsible for over 100,000 deaths annually and leaving another 300,000 individuals with permanent disabilities.In groundbreaking research, scientists have turned to de novo designed proteins as a novel approach to counteract these venom toxins. Using deep learning methods, researchers have successfully created protein designs that demonstrate potential as next-generation antivenom therapeutics.
In the realm of cellular biology, senescence has emerged as a pivotal process influencing both the progression of cancer and the onset of age-related diseases. Defined as a state where cells cease to divide but remain metabolically active, senescence acts as a double-edged sword. Key life sciences companies are pinning pipeline hopes in cracking this.
In the face of a rapidly changing climate, the concept of hydroclimate volatility has emerged as a critical area of study, highlighting the dramatic and often sudden fluctuations between extremely dry and wet conditions. This phenomenon poses significant challenges to both natural ecosystems and human societies
In the ever-evolving landscape of pharmaceutical marketing, the industry faces a delicate balance between informing the public and adhering to strict regulations. This challenge was thrust into the spotlight with the recent case of CSL Seqirus and the alleged promotion of their prescription-only Flucelvax Influenza vaccine on the social media platform LinkedIn.
We write to you today with a profound sense of alarm and a pressing need for urgent action. The events unfolding in the Antarctic are a stark harbinger of the dangers posed by climate change, and they demand an immediate and concerted global response.
The recently launched Lancet Commission on Racism and Child Health has embarked on a pioneering journey to unravel the profound impact of racism, xenophobia, and discrimination on child health worldwide. This editorial delves into the multifaceted dimensions of this issue, exploring the pathways through which racism affects health outcomes and highlighting the urgent need for systemic change.
Seung et Murthy ont développé la carte FlyWire pendant plus de quatre ans, en utilisant des images de microscopie électronique de tranches du cerveau de la mouche. Les chercheurs et leurs centaines de collègues du monde entier ont assemblé les données pour former une carte complète du cerveau à l'aide d'outils d'intelligence artificielle (IA). Il s'agit d'une immense réussite qui révolutionne déjà le domaine.
Dans le monde de la biotechnologie, qui évolue rapidement, la capacité de concevoir des protéines plus stables est un défi majeur. Les méthodes informatiques capables de prédire avec précision l'impact des mutations d'acides aminés sur la stabilité thermodynamique d'une protéine pourraient révolutionner le processus d'ingénierie des protéines. Entrez dans Stability Oracle, un nouveau cadre d'apprentissage profond qui surpasse les méthodes de pointe dans la prédiction des mutations de protéines thermodynamiquement stabilisantes.
L'atmosphère martienne primitive était autrefois riche en dioxyde de carbone, mais au fil du temps, cette atmosphère épaisse s'est considérablement amincie. Où est passé tout ce carbone ? La réponse se trouve peut-être dans les roches et les minéraux qui recouvrent la surface de Mars
Astronomers have revealed new research showing that millions of new solar system objects are likely to be detected by a brand-new facility, which is expected to come online later this year.
New research demonstrates that with collaboration between stakeholders, Australia can fully decarbonize its domestic and energy export economies by 2060 -- a feat requiring $6.2 trillion USD and around 110,000 square kilomters of land -- while avoiding harm to important areas for biodiversity […]
The effects of artificial intelligence on adolescents are nuanced and complex, according to a new report that calls on developers to prioritize features that protect young people from exploitation, manipulation and the erosion of real-world relationships.
A new study found exposure to specific tiny particles in air pollution during pregnancy are associated with increased risk of various negative birth outcomes.
A new study details processes that keep pollutants aloft despite a drop in emissions.
Après 11 ans, Boston Dynamics a fait ses adieux à son robot humanoïde ATLAS HD. L'entreprise de robotique explique qu'il est temps pour ATLAS de "se détendre et de se relaxer" à la retraite, laissant le nouvel ATLAS tout électrique prendre le relais. Cette vidéo a été partagée pour rappeler les grands et les moins grands moments d'ATLAS HD.
