DRUG DEVELOPMENT

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DRUG DEVELOPMENT

Revolutionizing Antivenom: The Quest to Neutralize Snake Venom with De Novo AI Designed Proteins

Revolutionizing Antivenom: The Quest to Neutralize Snake Venom with De Novo AI Designed Proteins

Snakebite envenoming poses a persistent threat to public health. The World Health Organization recognizes it as a neglected tropical disease, responsible for over 100,000 deaths annually and leaving another 300,000 individuals with permanent disabilities.In groundbreaking research, scientists have turned to de novo designed proteins as a novel approach to counteract these venom toxins. Using deep learning methods, researchers have successfully created protein designs that demonstrate potential as next-generation antivenom therapeutics.

AIScience
Revolutionizing Antivenom: The Quest to Neutralize Snake Venom with De Novo AI Designed Proteins

Revolutionizing Antivenom: The Quest to Neutralize Snake Venom with De Novo AI Designed Proteins

Snakebite envenoming poses a persistent threat to public health. The World Health Organization recognizes it as a neglected tropical disease, responsible for over 100,000 deaths annually and leaving another 300,000 individuals with permanent disabilities.In groundbreaking research, scientists have turned to de novo designed proteins as a novel approach to counteract these venom toxins. Using deep learning methods, researchers have successfully created protein designs that demonstrate potential as next-generation antivenom therapeutics.

PharmaScience
Targeting Cellular Senescence: A New Frontier in Combating Cancer and Age-Related Diseases

Targeting Cellular Senescence: A New Frontier in Combating Cancer and Age-Related Diseases

In the realm of cellular biology, senescence has emerged as a pivotal process influencing both the progression of cancer and the onset of age-related diseases. Defined as a state where cells cease to divide but remain metabolically active, senescence acts as a double-edged sword. Key life sciences companies are pinning pipeline hopes in cracking this.

AIPharmaScience
Stability Oracle: A Powerful Tool for Engineering Stable Proteins

Stability Oracle: A Powerful Tool for Engineering Stable Proteins

In the rapidly evolving world of biotechnology, the ability to engineer proteins with enhanced stability is a critical challenge. Computational methods that can accurately predict how amino acid mutations will impact a protein's thermodynamic stability could revolutionize the protein engineering process. Enter Stability Oracle, a new deep learning framework that outperforms state-of-the-art methods in predicting thermodynamically stabilizing protein mutations

Pharma
Blockchain Revolutionizing the Pharmaceutical Industry: Ensuring Transparency, Security and Efficiency

Blockchain Revolutionizing the Pharmaceutical Industry: Ensuring Transparency, Security and Efficiency

Blockchain technology has emerged as a game-changer in various sectors, and the pharmaceutical industry is no exception. With its decentralized and transparent nature, blockchain holds tremendous potential to revolutionize drug development, supply chain management, clinical trials, and patient data security

Pharma
The UK’s Prescription for the Future?

The UK’s Prescription for the Future?

The Life Sciences sector now finds itself facing intensifying global competition, with other nations aggressively courting the industry's prized assets and expertise. Meanwhile, the National Health Service (NHS) has grappled with the dual challenge of constrained budgets and the rising costs of newer, more innovative medicines

Science
A Single Therapy for Asthma: Engineering Long-Lived T Cells with Multi-Targeting Abilities

A Single Therapy for Asthma: Engineering Long-Lived T Cells with Multi-Targeting Abilities

Researchers at Tsinghua University in Beijing may have found an alternative approach that could push severe asthma into long-term remission with just a single treatment: engineering long-lived T cells with the unique ability to target multiple drivers of the condition simultaneously.

Pharma
The Promise of CAR T-Cells: Progress and Challenges in Cancer Immunotherapy

The Promise of CAR T-Cells: Progress and Challenges in Cancer Immunotherapy

Over a decade since the first clinical trials began, long-term follow-up data have affirmed CAR T-cells’ ability to induce durable remissions in certain patients. However, the therapy also faces challenges, as not all treated cancers respond equally well and toxicity remains a concern. Ongoing research aims to optimize various aspects of CAR T-cell treatment to improve outcomes on a broader scale.

  • Solar and electric-powered homes feel the effects...
    on February, 2025 at 11:19 pm

    An expert in energy technologies uses AI tools to investigate the impact of extreme weather on solar-powered and electrified homes and uncover their unique vulnerabilities and develop insights on how they handle harsh conditions.

  • Personalized cancer treatment using 3D...
    on February, 2025 at 5:27 pm

    Scientists have successfully developed a gastric cancer model using 3D bioprinting technology and patient-derived cancer tissue fragments. This innovative model preserves the characteristics of actual patient tissues and is expected to rapidly evaluate and predict individual patient drug responses.

  • Temperamental stars are distorting our view of...
    on February, 2025 at 5:24 pm

    'Temperamental' stars that brighten and dim over a matter of hours or days may be distorting our view of thousands of distant planets, suggests a new study.

  • Researchers achieve total synthesis of ibogaine
    on February, 2025 at 3:39 am

    Researchers have achieved total chemical synthesis of the psychoactive compound ibogaine and its analogs from pyridine. The discovery will make it easier to explore the therapeutic possibilities of ibogaine.

  • Multinational research project shows how life on...
    on February, 2025 at 9:47 pm

    Measurements and data collected from space can be used to better understand life on Earth. An ambitious, multinational research project has demonstrated that Earth's biodiversity can be monitored and measured from space, leading to a better understanding of terrestrial and aquatic ecosystems.

BBC Virtual Reality Rome

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Hubble Organisation

Since it launch on the Spacce Shuttle Discovery on On April 24, 1990, Hubble has revealed properties of space and time that for most of human history were only probed in the imaginations of scientists and philosophers. 

Sense About Science

Sense about Science is an independent charity that promotes the public interest in sound science and evidence. Founded in 2002, Sense about Science works with decision-makers, world-leading researchers and community groups to raise the standard of evidence in public life.

Chandra Observatory

Since its launch on July 23, 1999, the Chandra X-ray Observatory has been NASA’s flagship mission for X-ray astronomy, taking its place in the fleet of “Great Observatories.”

The IUCN Red List

Established in 1964, the International Union for Conservation of Nature’s Red List of Threatened Species has evolved to become the world’s most comprehensive information source on the global extinction risk status of animal, fungus and plant species.

Scott Hartman's Skeletal Drawings

Scott Hartman’s detailed and rigorous skeletal reconstructions set the standard for sauropods: he’s now become the first port of call when looking for precise, anatomically correct work.

After 11 years, Boston Dynamics has said goodbye to its humanoid robot ATLAS HD. The robotics company says it’s time for ATLAS to “kick back and relax” in retirement, letting the new all electric ATLAS take over. This video was shared to remember ATLAS HD’s great moments and those not so great.

 

Header Banner: Speed is the name of the game. The DarkDrug logo shows an Intel Xeon microchip die. Xeon is a brand of x86 microprocessors designed, manufactured, and marketed by Intel, targeted at the non-consumer workstation, server, and embedded system markets. It was introduced in June 1998. The advent ofoptical fibre cable has allowed the speed of data transmission to reach dizzy heights (shown in the DarkDrug logo). The field of applied science and engineering concerned with the design and application of optical fibers is known as fibre optics. The term was coined by Indian physicist Narinder Singh Kapany, who is widely acknowledged as the father of fibre optics.

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